Review-SI 2016; 2016:e00120

Science Insights, 08 March 2016
Volume 2016
Doi: 10.15354/si.16.re120
Review (Narrative)
Cancer: Intrinsic Versus Extrinsic Factors on Its Genesis
Winn J. Negri Jr, PhD*; Jackson M. Phillips, MD*; Cynthia Cree, PhD,
Author Affiliations
*: Cancer Biolab, Medical Center, Federal University of Rio de Janeiro, 550 - Cidade Universitária, Rio de Janeiro - RJ, 21941-901, Brazil
†: Cancer Biology, Division of Medicine and Public Health, The BASE, Chapel Hill, NC 27150, USA
∆: Correspondence to: Dr. Cynthia Cree,  Email:


Cancer as one of the leading causes of death has been a major concern for medical practitioners and researchers for many years, not just because of the diagnosis and treatment, but understanding the roles of intrinsic and extrinsic factors on its genesis. Some of the recent discoveries about cancer are the roles of xenobiotics and some internally produced biological molecules in forming tumors when brought in contact with living tissue. The discovery of the roles of intrinsic and extrinsic factors in mutagenesis has since been extensively examined with various experiments and data collected from neoplasm with the various carcinogens. The detailed studies of cancer genesis have proved that extrinsic factors, such as chemicals and radiation at different wavelengths, and some biological molecules play critical roles in mutagenesis. The main purpose of this review is to weigh the effects of the various factors (intrinsic and extrinsic) on cancer genesis.

KeywordsCancer; Risk factor; Pathogenesis; Mortality

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