COVID-19 is a disaster for mankind. With the gradual decrease in winter temperatures and the beginning of the holiday season, the number of COVID-19 infections has increased rapidly. In order to reduce the risk of COVID-19 infection, Insights Publisher will implement the second round of lockdown from December 23, 2020. The lockdown time is from December 23, 2020 to March 10, 2021. All editors will work from home. We sincerely apologize for any delays in manuscript review and publication caused by COVID-19 lockdown. Insights Publisher will do its best to reduce the backlog of manuscripts waiting to be processed. During this lockdown period, please email to editorial-office@bonoi.org for all contact with the Editorial Office.