Published Mar 22, 2020

Johnson S. Leonard  

Mary K. Pathak


With the legalization of recreational marijuana, the concerns about its potential negative impact on abusers’ cognitive and mental health have not been being discussed thoroughly. Driven by commercial interests, many marijuana-related scientific research results have not been well considered in the policy making process. When people subconsciously indulge in something that is already notorious, they avoid it and overemphasize what seems good, while using illogical analogies to obliterate the disadvantages. We herein will objectively review the potential short- and long-term effects of marijuana, so as to sound the alarm for the legal use of marijuana.



Marijuana, Cognition Distortion, Memory Impairment, Intelligence Decline, Addition Potential

1. Leonard JS, Pathak MK, Wang F. Marijuana and brain: The debating Focus of science and economy. Sci Insigt 2015; 13(3):501-508.

2. Lukas SE, Mendelson JH, Benedikt R. Electroencephalographic correlates of marihuana-induced euphoria. Drug Alcohol Depend 1995; 37(2):131-140.

3. Grunberg VA, Cordova KA, Bidwell LC, Ito TA. Can marijuana make it better? Prospective effects of marijuana and temperament on risk for anxiety and depression. Psychol Addict Behav 2015; 29(3):590-602.

4. Mikulskaya E, Martin FH. Contrast sensitivity and motion discrimination in cannabis users. Psychopharmacology (Berl) 2018; 235(8):2459-2469.

5. Vukadinovic Z, Herman MS, Rosenzweig I. Cannabis, psychosis and the thalamus: a theoretical review. Neurosci Biobehav Rev 2013; 37(4):658-667.

6. Temple LM. Medical marijuana and pain management. Dis Mon 2016; 62(9):346-352.

7. Hadley W, Barker D, Thamotharan S, Houck CD. Relationship between unsupervised time and participation in an emotion regulation intervention and risk outcomes. J Dev Behav Pediatr 2017; 38(9):714-722.

8. Busquets-Garcia A, Gomis-González M, Salgado-Mendialdúa V, Galera-López L, Puighermanal E, Martín-García E, Maldonado R, Ozaita A. Hippocampal protein kinase C signaling mediates the short-term memory impairment induced by delta9-tetrahydrocannabinol. Neuropsychopharmacology 2018; 43(5):1021-1031.

9. Bruijnen CJWH, Dijkstra BAG, Walvoort SJW, Markus W, VanDerNagel JEL, Kessels RPC, DE Jong CAJ. Prevalence of cognitive impairment in patients with substance use disorder. Drug Alcohol Rev 2019; 38(4):435-442.

10. Wilkinson ST, Radhakrishnan R, D'Souza DC. A systematic review of the evidence for medical marijuana in psychiatric indications. J Clin Psychiatry 2016; 77(8):1050-1064.

11. Zehra A, Burns J, Liu CK, Manza P, Wiers CE, Volkow ND, Wang GJ. Cannabis addiction and the brain: A review. J Neuroimmune Pharmacol 2018; 13(4):438-452.

12. Savage RJ, King VL, Clark CB, Cropsey KL. Factors associated with early marijuana initiation in a criminal justice population. Addict Behav 2017; 64:82-88.

13. Fischer BA, McMahon RP, Kelly DL, Wehring HJ, Meyer WA, Feldman S, Carpenter WT, Gorelick DA. Risk-taking in schizophrenia and controls with and without cannabis dependence. Schizophr Res 2015; 161(2-3):471-477.

14. Ortiz-Medina MB, Perea M, Torales J, Ventriglio A, Vitrani G, Aguilar L, Roncero C. Cannabis consumption and psychosis or schizophrenia development. Int J Soc Psychiatry 2018; 64(7):690-704.

15. Hamilton I. Cannabis, psychosis and schizophrenia: Unravelling a complex interaction. Addiction 2017; 112(9):1653-1657.

16. Jager G, Kahn RS, Van Den Brink W, Van Ree JM, Ramsey NF. Long-term effects of frequent cannabis use on working memory and attention: an fMRI study. Psychopharmacology (Berl) 2006; 185(3):358-368.

17. Andrade C. Cannabis and neuropsychiatry, 1: Benefits and risks. J Clin Psychiatry 2016; 77(5):e551-e554.

18. Palamar JJ, Griffin-Tomas M, Acosta P, Ompad DC, Cleland CM. A comparison of self-reported sexual effects of alcohol, marijuana, and ecstasy in a sample of young adult nightlife attendees. Psychol Sex 2018; 9(1):54-68.

19. Silva L, Zhao N, Popp S, Dow-Edwards D. Prenatal tetrahydrocannabinol (THC) alters cognitive function and amphetamine response from weaning to adulthood in the rat. Neurotoxicol Teratol 2012; 34(1):63-71.

20. Elkins IJ, Saunders GRB, Malone SM, Keyes MA, McGue M, Iacono WG. Associations between childhood ADHD, gender, and adolescent alcohol and marijuana involvement: A causally informative design. Drug Alcohol Depend 2018; 184:33-41.

21. Haas AL, Zamboanga BL, Bersamin M, Hyke T. Perceived access and parental monitoring as moderators of impulsivity and marijuana use among adolescents. J Prim Prev 2018; 39(2):155-169.

22. Nestor L, Roberts G, Garavan H, Hester R. Deficits in learning and memory: Parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users. Neuroimage 2008; 40(3):1328-1339.

23. Dong C, Chen J, Harrington A, Vinod KY, Hegde ML, Hegde VL. Cannabinoid exposure during pregnancy and its impact on immune function. Cell Mol Life Sci 2019; 76(4):729-743.

24. Sherman MP, Aeberhard EE, Wong VZ, Simmons MS, Roth MD, Tashkin DP. Effects of smoking marijuana, tobacco or cocaine alone or in combination on DNA damage in human alveolar macrophages. Life Sci 1995; 56(23-24):2201-2207.

25. Lowe HI, Toyang NJ, McLaughlin W. Potential of cannabidiol for the treatment of viral hepatitis. Pharmacognosy Res 2017; 9(1):116-118.

26. Russo C, Ferk F, Mišík M, Ropek N, Nersesyan A, Mejri D, Holzmann K, Lavorgna M, Isidori M, Knasmüller S. Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells. Arch Toxicol 2019; 93(1):179-188.

27. Hurd YL, Spriggs S, Alishayev J, Winkel G, Gurgov K, Kudrich C, Oprescu AM, Salsitz E. Cannabidiol for the reduction of cue-induced craving and anxiety in drug-abstinent individuals with heroin use disorder: A double-blind randomized placebo-controlled trial. Am J Psychiatry 2019; 176(11):911-922.

28. Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet 2003; 42(4):327-360.

29. Bonnet U, Preuss UW. The cannabis withdrawal syndrome: current insights. Subst Abuse Rehabil 2017; 8:9-37.
How to Cite
Leonard, J. S., & Pathak, . M. K. (2020). Legal Use of Marijuana: Will Scientific Evidence Overwhelm Self-Perceived High Feeling?. Science Insights, 32(3), 133-137. https://doi.org/10.15354/si.20.re051