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Published Feb 20, 2019

Jiwei Gu

Chunlian Liu

Zhenghao Huo  

Abstract

Cardiac hypertrophy is a frequent pathological reaction to hypertension, pulmonary hypertension, and other cardiovascular diseases. A typical feature of myocardial remodeling, cardiac hypertrophy can lead to heart failure and ultimately death. In recent years, studies have found some factors circulating within the blood of young mice can improve symptoms of heart hypertrophy in aged mice. GDF11 in the blood was once considered a key factor to extenuate cardiac hypertrophy, but subsequent studies question this conclusion. Recent genomic advances have revealed that non-coding RNA, including circular RNA, piRNAs, microRNAs and long non-coding RNAs, play an important role in gene expression and regulation, directly affecting pathophysiological mechanisms. The involvement of microRNAs within the myocardium and aortic valve in the regulation of pathophysiology may lead to the development of cardiovascular disease. Exosome-derived microRNA molecules in the heart are related to heart hypertrophy and failure. This article reviews the relevance of microRNAs to heart hypertrophy and the transported mechanism, which is helpful to discover new therapy and biomarkers for cardiac hypertrophy.

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Keywords

Cardiac Hypertrophy, Exosome, Heart Failure, microRNA

Supporting Agencies

National Natural Science Foundation (81660690); Ningxia Natural Sci- ence Foundation (2018AAC03144)

First-Class Discipline Construction Founded Project of NingXia Medical University and the School of Clinical Medicine (NXYLXK2017A05)

Innova- tion and Entrepreneurship Project for Over- seas Students in Ningxia Province.

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How to Cite
Gu, J., Liu, C., & Huo, . Z. (2019). miRNA and Cardiac Hypertrophy. Science Insights, 28(1), 17-24. https://doi.org/10.15354/si.19.re056
Section
Review