Gene editing is not limited to human and animal systems only but also in plant technology for improved food production. Gene editing have also been applied in disease control, manufacture of drugs, and vector control. The concept of gene-editing could accelerate the field of gene therapy as a major source of scientific and biotechnology circles. Utilization of this technology may have a number of positive impacts and consequently negative impacts on human life and the environment. Gene editing technology also comes with unintended consequences which offset any positive effects. It can be time-consuming to characterize the basic parameters in the system. Chinese scientists claimed to have successfully produced the first ever gene edited babies. The central objective of the procedure was to protect the twins from contracting HIV virus. Gene editing can result in an alteration of genes other than those targeted by scientists. Moreover, safety concerns have been raised and the Chinese scientists championing for its implementation have been asked to stop for a while. The researchers and scientists should, therefore, focus on advancing the technology in order to prove it safe and ethical. It is equally important to appreciate and improve on what the technology can do.
Gene-edited Baby, CRISPR-Cas9, Human Genome, Ethics, Science
2. Cyranoski D. CRISPR gene-editing tested in a person for the first time. Nat News 2016; 539(7630):479.
3. Georgiadis C, Qasim W. Emerging applications of gene edited T cells for the treatment of leukemia. Exp Rev Hematol 2017; 10(9):753-755.
4. Reardon S. Welcome to the CRISPR zoo. Nature 2016; 531(7593):160-163.
5. Harmon A. Open season is seen in gene editing of animals. New York Times, 2015; 27:A1.
6. Lunshof J. Regulate gene editing in wild animals. Nature 2015; 521(7551):127-127.
7. Human gene editing: Fire of Prometheus, or Box of Pandora?. Last access: November 11, 2018. Retrieved from https://news.cgtn.com/news/3d3d414d7749544f30457a6333566d54/share_p.html
8. Gartland KM, Dundar M, Beccari T, Magni MV, Gartland JS. Advances in biotechnology: Genomics and genome editing. Eur Biotech J 2017; 1(1):2-9.
9. Alice Klein M. World’s first gene-edited babies announced by a scientist in China. Last access: November 11, 2018. Retrieved from https://www.newscientist.com/article/2186504-worlds-first-gene-edited-babies-announced-by-a-scientist-in-china/
10. Mariscal C, Petropanagos A. CRISPR as a driving force: the Model T of biotechnology. Monash Bioethics Rev 2016; 34(2):101-116.
11. ‘Pandora’s box has been opened’: Scientist’s baby gene-editing claim fuels backlash. Last access November 11, 2018; Retrieved from https://conspiracyoz.com/2018/11/29/pandoras-box-has-been-opened-scientists-baby-gene-editing-claim-fuels-backlash/
12. Barrangou R. Cultivating CRISPR. CRISPR J 2018; 1(2):99-100.
13. Callaway E. Doubts raised about CRISPR gene-editing study in human embryos. Nat News 2017.
14. Regalado A. Engineering the perfect baby. MITS Technol Rev, 2015; 118(3):27-33.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.