Published Jul 25, 2016

Senzhu Bao  


Genetic engineering is a group of techniques that are being employed to change the genetic makeup of cells and move genes across the boundary of species to supply new organisms. There are a variety of techniques for moving genes by artificial means into recipient organisms.  These methods include using chemical or electrical treatments to facilitate direct DNA uptake by the host cells; microinjecting of genes directly into host cells; firing tiny metal particles covered with the genes of interest into host cells (bioballistics); and using plasmids found in bacteria. Advantages and disadvantages exist for genetic engineering. Some advantages include produce new foods, tackling and defeating diseases and getting rid of illnesses in young and unborn children. Some of the disadvantages are may lead to genetic defects and limits genetic diversity. Genetic Engineering is one of the most controversial topics of this century. It might work miraculously but who knows the consequences of playing with the nature.



Genetics, Medical Science, Engineering, Regeneration, Intervention

Supporting Agencies

This work is supported by the National Natural Scientific Foundation of China (81560200).

1. Smith JM. Seeds of deception: exposing industry and government lies about the safety of the genetically engineered foods you’re eating, 49 (Yes! Books 2003)

2. DNA from the beginning, a gene is a discrete sequence of DNA molecule (last visited July 19, 2009).

3. Kunich JC. Mother Frankenstein, Doctor Nature, and the Environmental Law of Genetic Engineering, 74 S. Cal. L. Rev. 807, 809 (2001).

4. Li Z, Liu ZB, Xing A, Moon BP, Koellhoffer JP, Huang L, Ward RT, Clifton E, Falco SC, Cigan AM. Cas9-Guide RNA Directed Genome Editing in Soy-bean. Plant Physiol 2015; 169:960-970.

5. Sophia Kolehmainen, Precaution Before Profits: An Overview of Issues on Genetically Engineered Food and Crops, 20 Va. Envtl. L.J. 267, 271 (2001).

6. Cibus. BASF and Cibus achieve de-velopment milestone in CLEAR-FIELD® production system (press re-lease). Undated. Available at: http://www.cibus.com/press/press012709.php.

7. Cibus. What is RTDSTM? The Rapid Trait Development System in brief. 2013. Available at: http://www.cibus.com/rtds.php.

8. Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol 2013; 31:822-826.

9. Latham JR, Wilson AK, Steinbrecher RA. The mutational consequences of plant transformation. J Biomed Bio-technol. 2006; 2006:1-7.

10. C. Free trade for “high-risk biotech”? Future of genetically engineered organisms, new synthetic genome technologies and the planned free trade agreement TTIP -a critical assess-ment. Munich, Germany: Testbiotech; 2013. Available at: https://www.testbiotech.org/sites/default/files/Testbiotech_Future_Biotech.pdf
How to Cite
Bao, S. (2016). Genetic Engineering: Pros versus Cons in Deciphering Disease Mechanism. Science Insights, 2016(12), 1-4. https://doi.org/10.15354/si.16.re203