Although pain is the most awful feeling for personal perception, it possesses critical benefits for preventing our human being to be injured further. Pain itself forms an overbalanced microenvironment in which people undertakes individualized changes in its neurobiological, psychological, endocrinological and genetic properties especially in the context of chronic pain or when the acute pain transmitted to chronicity. Our previous part (Part I) review the general epigenetic modification of nociceptive contributing factors in the context of chronic pain. Herein (Part II) we paid specific attention on the epigenetic regulation of pain-associated molecules including neurotransmitters and other factors. A detailed understanding of the specific modulating factors that influence individual epigenetic differences contributing to pain sensitivity and responsiveness to analgesics possesses essential implications in clinical pain management.
Pain, Gene Expression, Epigenetics, Analgesia, Neural Inhibition
This work is supported by the National Natural Scientific Foundation of China (81271242, 81371248).
BASE Foundation from Bonoi Academy of Science and Education (BASE2013002B).
Nanjing Outstanding Young Scientists Grant (JQX12009).
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