Postoperative pain is considered as a risk factor for the mortality of cancerous patients. Are there convincing evidence demonstrating the causality between them? It is hard to draw a conclusion from the currently available data. Pain itself is an immune suppressor and functions as a tumor-promoting mediator, but it is strongly associated with the pain intensity. The mild-to-moderate pain is a favorable factor to the recovery for patients from surgeries. Everything possesses dual facets: yin and yang balance system. What we need to do is how to take advantage of the favorable from both sides rather than debate which is superior to the other. Yes, even overbalance there, the key necessary for it is to taking measures to keep them on balance.
Postoperative Pain, Cancer, Mortality, Balance, Outcome
This work is supported in part by the Natural Scientific Foundation of China (NSFC, 30901397, 81271242, 81371248), Nanjing Municipal Outstanding Young Scientist in Medical Development (201208009), Nanjing Medical University Grant for Science & Technology Development (08NMUZ033), and Nanjing Municipal Foundation of Medical Science (ZKX10018).
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