Due to the uneven distribution of geochemical elements and environmental pollution caused by industrial development, the environmental media in some areas are rich in fluorine and arsenic. High-fluorine, high-arsenic, and double high regions of both fluorine and arsenic exist widely in the world. The attention to the harm of endemic fluoride, arsenic and their combined poisoning on the intelligence, learning and memory of children has been paid. We herein reviewed the research results on the effects of fluorine, arsenic and their combined effects on learning and memory.
Fluoride, Arsenic, Fluoride-Arsenic Poisoning, Learning and Memory, Intelligence Retardation
2. Huang YZ, Qian XC, Wang GQ, et al. Syndrome of endemic arsenism and fluorosis: A clinical study. Chin Med J (Engl) 1992; 105(7):586-590.
3. Calderón J, Machado B, Navarro ME, et al. Influence of fluoride on reaction time and organization visuospatial in children. Epidemiology 2001; 11:S153.
4. Rocha-Amador D, Navarro ME, Carrizales L, et al. Decreased intelligence in children and exposure to fluoride and arsenic in drinking water. Cad Saude Publica 2007; 23(Suppl 4):S579-S587.
5. Seraj B, Shahrabi M, Shadfar M, et al. Effect of high water fluoride concentration on the intellectual development of children in Makoo/Iran. J Dent (Tehran) 2012; 9(3):221-229.
6. Saxena S, Sahay A, Goel P. Effect of fluoride exposure on the intelligence of school children in Madhya Pradesh, India. J Neurosci Rural Pract 2012; 3(2):144-149.
7. Lu Y, Sun ZR, Wu LN, et al. Effect of high-fluoride water on intelligence in children. Fluoride 2000; 33(2):74-78.
8. Zhao LB, Liang GH, Zhang DN, et al. Effect of a high fluoride water supply on children’s intelligence. Fluoride 1996; 29(4):190-192.
9. Wang SX, Wang ZH, Cheng XT, et al. Arsenic and fluoride exposure in drinking water: children’s IQ and growth in Shanyin county, Shanxi province, China. Environ Health Perspect 2007; 115(4):643-647.
10. Ding Y, YanhuiGao, Sun H, et al. The relationships between low levels of urine fluoride on children’s intelli-gence, dental fluorosis in endemic fluorosis areas in Hulunbuir, Inner Mongolia, China. J Hazard Mater 2011; 186(2-3):1942-1946.
11. Liu M, Qian C. Meta-analysis of the effects of endemic fluorosis on children’s intellectual development. Chin J Contemp Pediat 2008; 10(6):723-725.
12. Tang QQ, Du J, Ma HH, et al. Fluoride and children’s intelligence: a meta-analysis. Biol Trace Elem Res 2008; 126(1-3):115-120.
13. Calderón J, Navarro ME, Jimenez-Capdeville ME, et al. Exposure to arsenic and lead and neuro-psychological development in Mexican children. Environ Res 2001; 85(2):69-76.
14. Rosado JL, Ronquillo D, Kordas K, et al. Arsenic exposure and cognitive performance in Mexican schoolchil-dren. Environ Health Perspect 2007; 115(9):1371-1375.
15. Tsai SY, Chou HY, The HW, et al. The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 2003; 24 (4-5):747-753.
16. Wright RO, Amarasiriwardena C, Woolf AD, et al. Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site. Neurotoxicology 2006; 27(2):210-216.
17. Wasserman GA, Liu X, Parvez F, et al. Water arsenic exposure and children’s intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004; 112(13):1329-1333.
18. Wasserman GA, Liu X, Parvez F, et al. Water arsenic exposure and intellectual function in 6-Year-Old Children in Araihazar, Bangladesh. Environ Health Perspect 2007; 115(2):285-289.
19. von Ehrenstein OS, Poddar S, Yuan Y. Children’s intellectual function in relation to arsenic exposure. Epide-miology 2007; 18(1):44-51.
20. Hamadani JD, Tofail F, Nermell B, et al. Critical windows of exposure for arsenic-associated impairment of cognitive function in pre-school girls and boys: a population-based cohort study. Int J Epidemiol 2011; 40( 6):1593-1604.
21. Kang J, Jin Y, Cheng Y, et al. Effects of drinking water on children’s intelligence. Health Res 2007; 36(3):347-349.
22. Hamadani JD, Grantham-McGregor SM, Tofail F, et al. Preand postnatal arsenic exposure and child development at 18 months of age: a cohort study in rural Bangladesh. Int J Epidemiol 2010; 39(5):1206-1216.
23. Zhang J, Yao H, Chen Y. Investigation on the effects of high arsenic and high fluoride on the intellectual development of offspring. Chin J Pub Health 1998; 17(2):119.
24. Chioca LR, Raupp IM, Da Cunha C, et al. Subchronic fluoride intake in-duces impairments in habituation and active avoidance tasks in rats. Eur J Pharmacol 2008; 579(1-3):196-201.
25. Wu CX, Gu XL, Ge YM, et al. Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats. Fluoride 2006; 39(4):274-279.
26. Wang JD, Ge YM, Ning HM, et al. Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats. Fluoride 2004; 37(3):201-208.
27. Zhang Z, Xu X, Shen X, et al. Effects of chronic fluorosis on learning and memory behavior and exercise en-durance in mice. Chin Pub Health 1999; 15(3):186-187.
28. Zhang Z, Shen X, Xu X. Improving effect of selenium on learning and memory impairment induced by fluoride in mice. Health Res 2001; 30(3):144-146.
29. Zhang Z, Shen X, Xu X. Effects of combined iodine and selenium on learning and memory impairment induced by fluoride in mice. Chin J Prevent Med 2003; 37(5):388-389.
30. Zhang Z, Xu X, Shen X, et al. Effects of fluoride poisoning on synaptic structure of learning and memory-related brain regions in mice. Health Res 1999; 28(4):210-212.
31. Xu X, Zhang Z, Shen X. Effects of fluoride poisoning on learning and memory behavior and SOD activity and MDA content in the brain of mice. Chin Pub Health 2001; 17(1):8-10.
32. Krüger K, Straub H, Binding N, et al. Effects of arsenite on long-term potentiation in hippocampal slices from adult and young rats. Toxicol Lett 2006; 165(2):167-173.
33. Rodriguez VM, Carrizales L, Jiminez-Capdeville ME, et al. The effects of sodium arsenite exposure on behavioral parameters in the rat. Brain Res Bull 2001; 55(2):301-308.
34. Nagaraja TN, Desiraju T. Effects on operant learning and brain acetylcholine esterase activity in rats following chronic inorganic arsenic intake. Hum Exp Toxicol 1994; 13(5):353-356.
35. Li H, Ye Z, Li H. Effects of arsenide on memory ability in rats. J Health Toxicol 1999; 13(1):36-37.
36. Xiao J, Zhang M, Pan Y, et al. Effects of chronic arsenic exposure on learning and memory function in rats. Chin J Med Physics 2006; 23(2):114-117.
37. Xi S, Sun G, Sun W, et al. Effects of arsenic on neural behavior and learning and memory function in offspring rats. Chin Pub Health 2006; 22(5):559-560.
38. Luo JH, Qiu ZQ, Shu WQ, et al. Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats. Toxicol Lett 2009; 184(2):121-125.
39. Luo J, Qiu Z, Shu W, et al. Effects of arsenic on hippocampal ultrastructure and NMDAR expression in rats. Chin Pub Health 2008; 24(12):1483-1485.
40. Li Y, Kang C, Zang G, et al. Effects of chronic arsenic poisoning on CA3 ultrastructure of hippocampus in rats. J Environ Health 2008; 25(6):517-519.
41. Zhang C, Ling B, Liu J, et al. Effects of fluoride and arsenic exposure on neurobehavioral development in rat offspring. J Health Res 1999; 28(6):337-338.
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