The Potential Use of Adipose-derived Stem Cells
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Abstract
The potential use of stem cell-based therapies for the repair and regeneration of different tissues and organs offers a paradigm shift that will give different therapeutic solutions for variety of diseases. The use of either embryonic stem cells (ESCs) or elicited pluripotent stem cells in clinical scenarios is restricted because of cell inability to divide and to technical and ethical concerns within the genetic manipulation of human ESCs, although these cells are, on paper, extremely helpful. Mesenchymal stem cells appear to be a perfect population of stem cells for sensible regenerative medicine, as they are not subjected to a similar kind of restrictions. Recent basic analyses and clinical studies have shown that the utilization of adipose-derived stem cells (ASCs) harvested from animal fat tissue in regenerative medication is not restricted to mesoblastic tissue, but extends to each germ layer and endodermal tissues and organs. Supported by this information, main purpose of this brief review is to summarize and describe the underlying biology of ASCs and their proliferation and differentiation capacities, alongside current diagnostic and clinical knowledge from a range of medical fields relating to the utilization of ASCs in regenerative drugs.
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Adipose-derived Stem Cells, Regenerative Medicine, Therapy Potentia, Pluripotential, Proliferation
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