Platelets are enucleate mobile fragments acknowledged for his or her important position in coagulation and vascular integrity. But, evidence is becoming more and clearer that platelets make contributions to various immunological strategies extending the past conventional view of platelets as fragmentary mediators of homeostasis and thrombosis. There may be current proof that platelets take part in: 1) intervention in opposition to microbial threats; 2) recruitment and promoting of innate effectors mobile capabilities; 3) modulating antigen presentation; and 4) enhancement of adaptive immune responses. In this way, platelets ought to be regarded as the underappreciated orchestrator of the immune system. This review will talk latest and ancient evidence regarding how platelets affect both innate and adaptive immune responses. As an instance, platelets have lately been proven to chemotaxis in response to specific stimuli and produce micro particles able to beginning each thrombosis and infection. The substantial role of platelets is a world still opens to exploration and could provide a non-stop source of amazement into the competencies of these anucleate cells.
Platelets, Immunity, Immunotherapy, Chemotaxis, Antigen Presenting Cells
2. Yeaman MR. Platelets: at the nexus of antimicrobial defence. Nat Rev Microbiol 2014; 12:426-437.
3. Sehgal S, Storrie B. Evidence that differential packaging of the major platelet granule proteins von Willebrand factor and fibrinogen can support their differential release. J Thromb Haemost 2007; 5:2009-2016.
4. Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008; 111:1227-1233.
5. Semple JW, Italiano JE Jr, Freedman J. Platelets and the immune continuum. Nat Rev Immunol 2011; 11:264-274.
6. Garraud O, Cognasse F. Are Platelets Cells? And if Yes, are They Immune Cells? Front Immunol 2015; 6:70.
7. Ghasemzadeh M, Hosseini E. Platelet-leukocyte crosstalk: Linking proinflammatory responses to procoagulant state. Thromb Res 2013; 131:191-197.
8. Gardiner EE, Andrews RK. Platelets: envoys at the infection frontline.J Infect Dis 2013; 208:871-873.
9. Cognasse F, Hamzeh-Cognasse H, Lafarge S, Delezay O, Pozzetto B, McNicol A, Garraud O. Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets. Br J Haematol 2008; 141:84-91.
10. Berthet J, Damien P, Hamzeh-Cognasse H, Arthaud CA, Eyraud MA, Zéni F, Pozzetto B, McNicol A, Garraud O, Cognasse F. Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion. Clin Immunol 2012; 145:189-200.
11. Hamzeh-Cognasse H, Damien P, Chabert A, Pozzetto B, Cognasse F, Garraud O. Platelets and infections - complex interactions with bacteria. Front Immunol 2015; 6:82.
12. Kraemer BF1, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS. Novel anti-bacterial activities of beta-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog 2011; 7:e1002355.
13. Claes J, Vanassche T, Peetermans M, Liesenborghs L, Vandenbriele C, Vanhoorelbeke K, Missiakas D, Schneewind O, Hoylaerts MF, Heying R, Verhamme P. Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor-binding protein. Blood 2014; 124:1669-1676.
14. Arman M, Krauel K, Tilley DO, Weber C, Cox D, Greinacher A, Kerrigan SW, Watson SP. Amplification of bacteria-induced platelet activation is triggered by Fc-gamma-RIIA, integrin alpha-IIb-beta3, and platelet factor 4. Blood 2014; 123:3166-174.
15. Vanassche T, Kauskot A, Verhaegen J, Peetermans WE, van Ryn J, Schneewind O, Hoylaerts MF, Verhamme P. Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation. Thromb Haemost 2012; 107:1107-1121.
16. Svensson L, Baumgarten M, Mörgelin M, Shannon O. Platelet activation by Streptococcus pyogenes leads to entrapment in platelet aggregates, from which bacteria subsequently escape. Infect Immun 2014; 82:4307-4314.
17. de Stoppelaar SF, Claushuis TA, Jansen MP, Hou B, Roelofs JJ, van't Veer C, van der Poll T. The role of platelet MyD88 in host response during gram-negative sepsis. J Thromb Haemost 2015; 13:1709-1720.
18. Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman GA. Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol 2012; 34:5-30.
19. McMorran BJ, Marshall VM, de Graaf C, Drysdale KE, Shabbar M, Smyth GK, Corbin JE, Alexander WS, Foote SJ. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 2009; 323:797-800.
20. van der Heyde HC1, Gramaglia I, Sun G, Woods C. Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokines. Blood 2005; 105:1956-1963.
21. Cox D, McConkey S. The role of platelets in the pathogenesis of cerebral malaria. Cell Mol Life Sci 2010; 67:557-568.
22. Aggrey AA, Srivastava K, Ture S, Field DJ, Morrell CN. Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria. J Immunol 2013; 190:4685-4691.
23. Solomon Tsegaye T, Gnirß K, Rahe-Meyer N, Kiene M, Krämer-Kühl A, Behrens G, Münch J, Pöhlmann S. Platelet activation suppresses HIV-1 infection of T cells. Retrovirology 2013; 10:48.
24. Simon AY, Sutherland MR, Pryzdial EL. Dengue virus binding and replication by platelets. Blood 2015; 126:378-385.
25. Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD. Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. Blood 2013; 121:1008-1015.
26. Kasperska-Zajac A. Recovery of platelet factor 4 (PF-4) and beta-thromboglobulin (beta-TG) plasma concentrations during remission in patients suffering from atopic dermatitis. Platelets 2010; 21:522-524.
27. Devi S, Kuligowski MP, Kwan RY, Westein E, Jackson SP, Kitching AR, Hickey MJ. Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway. Am J Pathol 2010; 177:1131-1142.
28. Kaneider NC, Kaser A, Tilg H, Ricevuti G, Wiedermann CJ. CD40 ligand-dependent maturation of human monocyte-derived dendritic cells by activated platelets. Int J Immunopathol Pharmacol 2003; 16:225-231.
29. Lo SC, Hung CY, Lin DT, Peng HC, Huang TF. Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activation. J Biomed Sci 2006; 13:787-796.
30. Vasina EM, Cauwenberghs S, Feijge MA, Heemskerk JW, Weber C, Koenen RR. Microparticles from apoptotic platelets promote resident macrophage differentiation. Cell Death Dis 2011; 2:e211.
31. Elzey BD, Sprague DL, Ratliff TL. The emerging role of platelets in adaptive immunity. Cell Immunol 2005; 238:1-9.
32. Chapman LM, Aggrey AA, Field DJ, Srivastava K, Ture S, Yui K, Topham DJ, Baldwin WM III, Morrell CN. Platelets present antigen in the context of MHC class I. J Immunol 2012; 189:916-923.
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