Published Oct 28, 2018

Juan R. Carson  


The articular cartilage repair can be achieved through different ways that is cell based repair, articular cartilage transplant, the use of micro fracture technique, the use of osteochondral autograft transplant, palliative care and the use of cell and scaffold technology. Articular cartilage repair is ineffective in some cases depending on the method which is used in the repair processes. The replacement does not help most of the patients, and this has dramatically resulted in other adverse effects to the clients. The majority of the patients who have adverse symptoms and considerable tear damage of tissues do not heal faster. The surgeons should take advantage of the rapidly growing technology in the field of medicine. This will help them to adopt those technologically based modes of articular cartilage methods which are more effective than those other method. The processes should be conducted with a lot of care as any defect can lead to further damage to the articular cartilage tissues which are very delicate.



Cartilage, Articular Joint, Osteoarthritis, Regeneration, Bioengineering

1. Reddi AH. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotech 2018; 16(3):247.

2. Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB. The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orth Res 2016;19(1):11-17.

3. Mauck RL, Nicoll SB, Seyhan SL, Ateshian GA, Hung CT. Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering. Tissue Engineer 2017; 9(4):597-611.

4. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. In The Biomaterials: Silver Jubilee Compendium 2016; pp175-pp189.

5. Chu CR, Coutts RD, Yoshioka M, Harwood FL, Monosov AZ, Amiel D. Articular cartilage repair using allogeneic perichondrocyteseeded biodegradable porous polylactic acid (PLA): A tissue-engineering study. J Biomed Mat Res 2016; 29(9):1147-1154.

6. Mauck RL, Soltz M A, Wang CC, Wong DD, Chao PHG, Valhmu WB, .Ateshian GA. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Engineer 2016; 122(3):252-260.

7. Moutos FT, Freed LE, Guilak F. A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nat Mat 2017; 6(2):162.

8. Suh JKF, Matthew HW. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials 2015; 21(24):2589-2598.

9. Cohen BP, Bernstein JL, Morrison KA, Spector JA, Bonassar LJ. Tissue engineering the human auricle by auricular chondrocyte-mesenchymal stem cell co-implantation. PLoS One 2018; 13(10):e0202356.

10. Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarth Cart 2014; 10(6):432-463.

11. Davisson T, Kunig S, Che, A, Sah R, Ratcliffe A. Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage. J Orth Res 2016; 20(4):842-848.

12. Temenoff JS, Mikos AG. Tissue engineering for regeneration of articular cartilage. Biomaterials 2014; 21(5):431-440.

13. Caldwell KL, Wang J. Cell-based articular cartilage repair: the link between development and regeneration. Osteoarth Cart, 2015; 23(3):351-362.

14. Yu Y, Brouillette MJ, Seol D, Zheng H, Buckwalter JA, Martin JA. Functional full-thickness articular cartilage repair by rhSDF-1alpha loaded fibrin/ha hydrogel network via chondrogenic progenitor cells homing. Arthritis Rheumatol 2015; 10:1002.

15. Hung CT, Mauck RL, Wang CCB, Lima EG, Ateshian GA. A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading. Annal Biomed Engineer 2014; 32(1):35-49.

16. Musumeci G, Castrogiovanni P, Leonardi R, Trovato FM, Szychlinska MA, Di Giunta A, . Castorina S. New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review. World J Orth, 2014; 5(2):80.

17. Orth P, Duffner J, Zurakowski D, Cucchiarini M, Madry H. Small-diameter awls improve articular cartilage repair after microfracture treatment in a translational animal model. Am J Sport Med 2016; 44(1):209-219.

18. Cucchiarini M, Madry H, Guilak F, Saris DB, Stoddart MJ, Koon Wong M, Roughley P. A vision on the future of articular cartilage repair. Eur Cell Mater 2014; 27(12): 6.

19. Estes BT, Guilak F, Moutos FT. US Patent Application No. 10/022,231. 2018.

20. Wall A, Board T. The biological effect of continuous passive motion on the healing of full-thickness defects in articular cartilage. An experimental investigation in the rabbit.Springer, London. In Classic Papers in Orthopaedics 2014; pp437-pp439.
How to Cite
Carson, J. R. (2018). Articular Cartilage Repair. Science Insights, 2018(11), 1–4. https://doi.org/10.15354/si.18.re082