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Published Sep 10, 2016

Ayman T. Bridgewater

Michael P. Worden Worden

Fuzhou Wang  

Abstract

Cloning is basically a biological mechanism in which parthenogenetic reproduction employed by one or more genetically identical cells, plants or organisms are derived from one parent. The word clone is from the Greek word “klon”, meaning a twig or slip from a plant. By taking many cuttings from one parent plant, genetic replicas with identical features and functions can be developed. The recent successful cloning from an adult sheep cell has raised the possibility of using asexual means to replicate humans. Through cloning the following clinical questions might be resolved: the course of spontaneous abortions, embryogenesis, carcinogenesis, and the use of embryonic tissue for transplantation. However, reproducing humans by use of cloning has raises serious legal, religious, and social problems. There are two methods used for cloning humans namely nuclear cloning and embryo splitting. Nuclear cloning in human reproduction should be prohibited because there are no extra major benefits by its application. It can only create additional medical, ethical, and social problems. The potential of cloning by embryo splitting for minimizing clinical costs and risks as well as increasing the rate of success for couples who are infertile and having children for them is a challenge. The minor legal and religious problems can finally be settled. If policymaker’s guidelines win international acceptance and if they succeed, it may take less time to reach this goal.

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Keywords

Clone, Human Being, Medicine, Ethnicity, Reproduction

References
1. Dorland's Illustrated Medical Dictionary, 28th ed. Philadelphia, W. B. Saunders, 1994, pp342.

2. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Cloning Stem Cells 2007; 9:3-7.

3. Trent RJ. Cloning. Bailliere's Clin Obstet Gynecol 1991; 5:659-673.

4. Willadsen SM. Nuclear transplantation in sheep embryos. Nature 1986; 320:63-65.

5. Prather RS, Barnes FL, Sims MM, Robl JM, Eyestone WH, First NL. Nuclear transplantation in the bovine embryo: assessment of donor nuclei and recipient oocyte. Biol Reprod 1987; 37:859-866.

6. Gurdon JB. Transplanted nuclei and cell differentiation. Sci Am 1968; 219:24-35.

7. Illmensee K, Hoppe PC. Nuclear transplantation in Musmusculus: Developmental potential of nuclei from preimplantation embryos. Cell 1981; 23:9-18.

8. Slice SL, Robl JM. Nuclear reprogramming in nuclear transplant rabbit embryos. Biol Reprod 1988; 39:657-664.

9. Campbell KHS, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996; 380:64-66.

10. Bondioli KR, Westhusin ME, Looney CR. Production of identical bovine of offspring by nuclear transfer. Theriogenology 1990; 33:165-174.

11. Robl JM, Stice SL. Prospects for the commercial cloning of animals by nuclear transplantation. Theriogenology 1989; 31:75-84.

12. Robl JM, Prather R, Barnes F, Eyestone W, Northey D, Gilligan B, First NL. Nuclear transplantation in bovine embryos. J Anim Sci 1987; 67:642-647.

13. Solter D. Lambing by nuclear transfer. Nature 1996; 380:24-25.

14. Otaegui PJ, O'Neill GT, Campbell KH, Wilmut I. Transfer of nuclei from 8-cell stage mouse embryos following use of nocodazole to control the cell cycle. Mol Reprod Dev 1994; 39:147-152.

15. Smith LC, Wilmut I, Hunter RH. Influence of cell cycle stage at nuclear transplantation on the development in vitro of mouse embryos. J Reprod Fertil 1988; 84:619-624.

16. Campbell KH, Ritchie WA, Wilmut I. Nuclear-cytoplasmic interactions during the first cycle of nuclear transfer reconstructed bovine embryos: Implications for deoxyribonucleic acid replication and development. Biol Reprod 1993; 49: 933-942.

17. Barnes FL, Collas P Powell, King WA, Westhusin M, Shepherd D. Influence of recipient oocyte cell stage on DNA synthesis, nuclear envelope breakdown, chromosome constitution, and development in nuclear transplant bovine embryos. Mol Reprod Dev 1993; 36:33-41.

18. Cheong HT, Takahashi Y Kanagawa H. Birth of mice after transplantation of early cell-cycle-stage embryonic nuclei into enucleated oocytes. Biol Reprod 1993; 48:958-963.

19. Stewart C. Nucleartransplantation. An udderway of making lambs. Nature 1997; 385:769-771.

20. Fulka J Jr, Horska M, Moor RM, Fulka J, Kanka J. Oocyte specific modulation of female pronuclear development in mice. Dev Biol 1996; 178:1-12.

21. Tycko B. Genomic imprinting: Mechanism and role in human pathology. Am J Pathol 1994; 144:43-443.

22. Hall JG. Genomic imprinting: Review and relevance to human disease. Am J Hum Genet 1990; 46:857-873.

23. Solter DA. Differential imprinting and expression of maternal and paternal genomes. Annu Rev Genet 1988; 22:127-146.

24. 22:127-146 24. Briggs R, King TJ. Transplantation of living nuclei from blastula cells into enucleated frogs' eggs. Zoology 1952: 38:455-463.

25. Baker RD, Shea BF. Commercial splitting of bovine embryos. Theriogenology 1985; 23:2-12.

26. Wolf D. Cloning of rhesus monkeys. Internet 1997.

27. Romeo G, Devoto M, Galietta LJ. Why is the cystic fibrosis gene so frequent? Hum Genet 1989; 84:1-5.

28. Hall JL, Engel D, Gindoff PR, et al. Experimental cloning of human polyploid embryos using an artificial zona pellucida. Annual meeting of the American Fertility Society and the Canadian Fertility and Andrology Society, 1993, abstr. O-001, pp81.

29. Handyside AH, Hardy K, Winston RML. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature 1990; 344:768-770.

30. Writer S. 2008 MPs support embryology proposals. BBC News Online. Available at news.bbc.co.uk/2/hi/uk_news/politics/7682722.stm. Accessed March 1, 2016.

31. UK Statute Law Database. Text of the human fertilisation and embryology (research purposes) regulations 2001 (no. 188). Available at www.legislation.gov.uk/uksi/2001/188/contents/made. Accessed March 1, 2016.

32. Kfoury C. Therapeutic cloning: Promises and issues. McGill J Med 2007; 10:112-120.
How to Cite
Bridgewater, A. T., Worden, M. P. W., & Wang, F. (2016). Human Cloning: Who’s Concern?. Science Insights, 2016(15), 1–8. https://doi.org/10.15354/si.16.ps020
Section
Perspective