Pathogenesis and Nutritional Intervention of Chronic Obstructive Pulmonary Disease-Associated Frailty
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Published
Dec 31, 2022
Abstract
Frailty, as a type of geriatric condition, has been a major focus of geriatrics researchers in recent years. COPD is one of the major risk factors associated with frailty. Consequently, chronic obstructive pulmonary disease-related frailty has become the focal point of numerous investigations. However, the majority of studies focus on cross-sectional investigations of the incidence of frailty in COPD and their associations. The study of its pathophysiology and intervention methods is dispersed, and there is a paucity of literature reviews. Moreover, in-depth research into the pathophysiology of such patients and the implementation of efficient therapeutic strategies are crucial for enhancing the long-term quality of life of patients. The purpose of this article is to provide a reference for creating nutritional intervention programs for chronic obstructive pulmonary disease and a debilitated population by describing the etiology of these patients and summarizing potential nutritional therapies based on recent research.
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Keywords
Lung Disease, Chronic Obstructive Pulmonary Disease, Frailty, Pathogenesis, Intervention
References
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3. Stellefson M, Paige SR, Barry AE, Wang MQ, Apperson A. Risk factors associated with physical and mental distress in people who report a COPD diagnosis: latent class analysis of 2016 behavioral risk factor surveillance system data. Int J Chron Obstruct Pulmon Dis 2019; 14:809-822. DOI: https://doi.org/10.2147/COPD.S194018
4. Mori H, Tokuda Y. Differences and overlap between sarcopenia and physical frailty in older community-dwelling Japanese. Asia Pac J Clin Nutr 2019; 28(1):157-165. DOI: https://doi.org/10.6133/apjcn.201903_28(1).0021
5. Zhao J, Huang Y, Yu X. A narrative review of gut-muscle axis and sarcopenia: The potential role of gut microbiota. Int J Gen Med 2021; 14:1263-1273. DOI: https://doi.org/10.2147/IJGM.S301141
6. Han H, Yi B, Zhong R, Wang M, Zhang S, Ma J, Yin Y, Yin J, Chen L, Zhang H. From gut microbiota to host appetite: Gut microbiota-derived metabolites as key regulators. Microbiome 2021; 9(1):162. DOI: https://doi.org/10.1186/s40168-021-01093-y
7. Dalile B, Van Oudenhove L, Vervliet B, Verbeke K. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol 2019; 16(8):461-478. DOI: https://doi.org/10.1038/s41575-019-0157-3
8. Hénique C, Mansouri A, Vavrova E, Lenoir V, Ferry A, Esnous C, Ramond E, Girard J, Bouillaud F, Prip-Buus C, Cohen I. Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype. FASEB J 2015; 29(6):2473-2483. DOI: https://doi.org/10.1096/fj.14-257717
9. Han Q, Huang X, Yan F, Yin J, Xiao Y. The role of gut microbiota in the skeletal muscle development and fat deposition in pigs. Antibiotics (Basel) 2022; 11(6):793. DOI: https://doi.org/10.3390/antibiotics11060793
10. Sprooten RTM, Lenaerts K, Braeken DCW, Grimbergen I, Rutten EP, Wouters EFM, Rohde GGU. Increased small intestinal permeability during severe acute exacerbations of COPD. Respiration 2018; 95(5):334-342. DOI: https://doi.org/10.1159/000485935
11. Kirschner SK, Deutz NEP, Jonker R, Olde Damink SWM, Harrykissoon RI, Zachria AJ, Dasarathy S, Engelen MPKJ. Intestinal function is impaired in patients with Chronic Obstructive Pulmonary Disease. Clin Nutr 2021; 40(4):2270-2277. DOI: https://doi.org/10.1016/j.clnu.2020.10.010
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13. Chan SMH, Selemidis S, Bozinovski S, Vlahos R. Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): Clinical significance and therapeutic strategies. Pharmacol Ther 2019; 198:160-188. DOI: https://doi.org/10.1016/j.pharmthera.2019.02.013
14. O’Donnell R, Breen D, Wilson S, Djukanovic R. Inflammatory cells in the airways in COPD. Thorax 2006; 61(5):448-454. DOI: https://doi.org/10.1136/thx.2004.024463
15. King PT. Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer. Clin Transl Med 2015; 4(1):68. DOI: https://doi.org/10.1186/s40169-015-0068-z
16. Chakraborty RK, Burns B. Systemic inflammatory response syndrome. [Updated 2022 May 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK547669/
17. Straub RH. Interaction of the endocrine system with inflammation: A function of energy and volume regulation. Arthritis Res Ther 2014; 16(1):203. DOI: https://doi.org/10.1186/ar4484
18. Webster JM, Kempen LJAP, Hardy RS, Langen RCJ. Inflammation and skeletal muscle wasting during cachexia. Front Physiol 2020; 11:597675. DOI: https://doi.org/10.3389/fphys.2020.597675
19. Wüst RC, Degens H. Factors contributing to muscle wasting and dysfunction in COPD patients. Int J Chron Obstruct Pulmon Dis 2007; 2(3):289-300.
20. Gea J, Pascual S, Casadevall C, Orozco-Levi M, Barreiro E. Muscle dysfunction in chronic obstructive pulmonary disease: Update on causes and biological findings. J Thorac Dis 2015; 7(10):E418-E438. DOI: https://doi.org/10.3978/j.issn.2072-1439.2015.08.04
21. Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging 2018; 13:757-772. DOI: https://doi.org/10.2147/CIA.S158513
22. Goodpaster BH, Chomentowski P, Ward BK, Rossi A, Glynn NW, Delmonico MJ, Kritchevsky SB, Pahor M, Newman AB. Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: A randomized controlled trial. J Appl Physiol (1985) 2008; 105(5):1498-1503. DOI: https://doi.org/10.1152/japplphysiol.90425.2008
23. Bogdanis GC. Effects of physical activity and inactivity on muscle fatigue. Front Physiol 2012; 3:142. DOI: https://doi.org/10.3389/fphys.2012.00142
24. McGuinness AJ, Sapey E. Oxidative stress in COPD: Sources, markers, and potential mechanisms. J Clin Med 2017; 6(2):21. DOI: https://doi.org/10.3390/jcm6020021
25. Fischer BM, Voynow JA, Ghio AJ. COPD: Balancing oxidants and antioxidants. Int J Chron Obstruct Pulmon Dis 2015; 10:261-276. DOI: https://doi.org/10.2147/COPD.S42414
26. Vézina FA, Cantin AM. Antioxidants and chronic obstructive pulmonary disease. Chronic Obstr Pulm Dis 2018; 5(4):277-288. DOI: https://doi.org/10.15326/jcopdf.5.4.2018.0133
27. Solsona R, Pavlin L, Bernardi H, Sanchez AM. Molecular regulation of skeletal muscle growth and organelle biosynthesis: Practical recommendations for exercise training. Int J Mol Sci 2021; 22(5):2741. DOI: https://doi.org/10.3390/ijms22052741
28. Hung CM, Garcia-Haro L, Sparks CA, Guertin DA. mTOR-dependent cell survival mechanisms. Cold Spring Harb Perspect Biol 2012; 4(12):a008771. DOI: https://doi.org/10.1101/cshperspect.a008771
29. Dibble CC, Cantley LC. Regulation of mTORC1 by PI3K signaling. Trends Cell Biol 2015; 25(9):545-555. DOI: https://doi.org/10.1016/j.tcb.2015.06.002
30. Vainshtein A, Sandri M. Signaling pathways that control muscle mass. Int J Mol Sci 2020; 21(13):4759. DOI: https://doi.org/10.3390/ijms21134759
31. Dodds R, Sayer AA. Sarcopenia and frailty: New challenges for clinical practice. Clin Med (Lond) 2016; 16(5):455-458. DOI: https://doi.org/10.7861/clinmedicine.16-5-455
32. Antoniu SA, Boiculese LV, Prunoiu V. Frailty, a dimension of impaired functional status in advanced COPD: Utility and clinical applicability. Medicina (Kaunas) 2021; 57(5):474. DOI: https://doi.org/10.3390/medicina57050474
33. Al-Mudares F, Reddick S, Ren J, Venkatesh A, Zhao C, Lingappan K. Role of growth differentiation factor 15 in lung disease and senescence: Potential role across the lifespan. Front Med (Lausanne) 2020; 7:594137. DOI: https://doi.org/10.3389/fmed.2020.594137
34. Patel MS, Lee J, Baz M, Wells CE, Bloch S, Lewis A, Donaldson AV, Garfield BE, Hopkinson NS, Natanek A, Man WD, Wells DJ, Baker EH, Polkey MI, Kemp PR. Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo. J Cachexia Sarcopenia Muscle 2016; 7(4):436-448. DOI: https://doi.org/10.1002/jcsm.12096
35. Re Cecconi AD, Forti M, Chiappa M, Zhu Z, Zingman LV, Cervo L, Beltrame L, Marchini S, Piccirillo R. Musclin, A myokine induced by aerobic exercise, retards muscle atrophy during cancer cachexia in mice. Cancers (Basel) 2019; 11(10):1541. DOI: https://doi.org/10.3390/cancers11101541
36. Tanaka R, Sugiura H, Yamada M, Ichikawa T, Koarai A, Fujino N, Yanagisawa S, Onodera K, Numakura T, Sato K, Kyogoku Y, Sano H, Yamanaka S, Okazaki T, Tamada T, Miura M, Takahashi T, Ichinose M. Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2018; 13:1333-1342. DOI: https://doi.org/10.2147/COPD.S157035
37. Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 2017; 9(9):1021. DOI: https://doi.org/10.3390/nu9091021
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How to Cite
Heo, J. (2022). Pathogenesis and Nutritional Intervention of Chronic Obstructive Pulmonary Disease-Associated Frailty. Science Insights, 41(7), 761–767. https://doi.org/10.15354/si.22.re105
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