Human Cardiac Development and Regeneration Modeling
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Published
Aug 29, 2024
Abstract
Human cardiac development and regeneration modeling are crucial areas of research that hold immense promise for advancing regenerative medicine and treating cardiovascular diseases. Understanding the intricate process of cardiac development, from the formation of the primitive heart tube to the maturation of the fetal heart, provides insights into potential therapeutic strategies for cardiac regeneration. This article explores the key stages of cardiac development, factors influencing cardiac regeneration, current models for studying regenerative processes, challenges and opportunities in regenerative medicine, future directions in cardiac development research, clinical applications of regenerative modeling, and the implications for healthcare. By delving into these aspects, researchers and healthcare professionals can gain a deeper understanding of how to harness the regenerative potential of the human heart for improved patient outcomes.
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Keywords
Human Heart, Cardiac Development, Regeneration, Modeling, Therapeutics
References
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2. Christoffels V, Jensen B. Cardiac morphogenesis: Specification of the four-chambered heart. Cold Spring Harb Perspect Biol 2020; 12(10):a037143. DOI: https://doi.org/10.1101/cshperspect.a037143
3. Liu Y, Chen S, Zühlke L, Black GC, Choy MK, Li N, Keavney BD. Global birth prevalence of congenital heart defects 1970-2017: Updated systematic review and meta-analysis of 260 studies. Int J Epidemiol 2019; 48(2):455-463. DOI: https://doi.org/10.1093/ije/dyz009
4. Wu W, He J, Shao X. Incidence and mortality trend of congenital heart disease at the global, regional, and national level, 1990-2017. Medicine (Baltimore) 2020; 99(23):e20593. DOI: https://doi.org/10.1097/MD.0000000000020593
5. Hashimoto H, Olson EN, Bassel-Duby R. Therapeutic approaches for cardiac regeneration and repair. Nat Rev Cardiol 2018; 15(10):585-600. DOI: https://doi.org/10.1038/s41569-018-0036-6
6. Kloesel B, DiNardo JA, Body SC. Cardiac embryology and molecular mechanisms of congenital heart disease: A primer for anesthesiologists. Anesth Analg 2016; 123(3):551-569. DOI: https://doi.org/10.1213/ANE.0000000000001451
7. Anderson RH, Webb S, Brown NA, Lamers W, Moorman A. Development of the heart: (2) Septation of the atriums and ventricles. Heart 2003; 89(8):949-958. DOI: https://doi.org/10.1136/heart.89.8.949
8. Saxton A, Chaudhry R, Manna B. Anatomy, Thorax, Heart Right Coronary Arteries. [Updated 2023 Jul 24]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK537357/
9. Hinton RB, Yutzey KE. Heart valve structure and function in development and disease. Annu Rev Physiol 2011; 73:29-46. DOI: https://doi.org/10.1146/annurev-physiol-012110-142145
10. Patra C, Zhang X, Brady MF. Physiology, Bundle of His. [Updated 2023 May 1]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK531498/
11. Ripa R, George T, Shumway KR, et al. Physiology, Cardiac Muscle. [Updated 2023 Jul 30]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK572070/
12. Tan CMJ, Lewandowski AJ. The transitional heart: From early embryonic and fetal development to neonatal life. Fetal Diagn Ther 2020; 47(5):373-386. DOI: https://doi.org/10.1159/000501906
13. Chaudhry R, Miao JH, Rehman A. Physiology, Cardiovascular. [Updated 2022 Oct 16]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK493197/
14. Nesselmann C, Ma N, Bieback K, Wagner W, Ho A, Konttinen YT, Zhang H, Hinescu ME, Steinhoff G. Mesenchymal stem cells and cardiac repair. J Cell Mol Med 2008; 12(5B):1795-810. DOI: https://doi.org/10.1111/j.1582-4934.2008.00457.x. Erratum in: J Cell Mol Med 2008; 12(6B):2875.
15. Guo Y, Yu Y, Hu S, Chen Y, Shen Z. The therapeutic potential of mesenchymal stem cells for cardiovascular diseases. Cell Death Dis 2020; 11(5):349. DOI: https://doi.org/10.1038/s41419-020-2542-9
16. Karantalis V, Hare JM. Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res 2015; 116(8):1413-1430. DOI: https://doi.org/10.1161/CIRCRESAHA.116.303614
17. Youssef AA, Ross EG, Bolli R, Pepine CJ, Leeper NJ, Yang PC. The promise and challenge of induced pluripotent stem cells for cardiovascular applications. JACC Basic Transl Sci 2016; 1(6):510-523. DOI: https://doi.org/10.1016/j.jacbts.2016.06.010
18. Xiang M, Lu M, Quan J, Xu M, Meng D, Cui A, Li N, Liu Y, Lu P, Kang X, Wang X, Sun N, Zhao M, Liang Q, Le L, Wang X, Zhang J, Chen S. Direct in vivo application of induced pluripotent stem cells is feasible and can be safe. Theranostics 2019; 9(1):290-310. DOI: https://doi.org/10.7150/thno.28671
19. Rikhtegar R, Pezeshkian M, Dolati S, Safaie N, Afrasiabi Rad A, Mahdipour M, Nouri M, Jodati AR, Yousefi M. Stem cells as therapy for heart disease: iPSCs, ESCs, CSCs, and skeletal myoblasts. Biomed Pharmacother 2019; 109:304-313. DOI: https://doi.org/10.1016/j.biopha.2018.10.065
20. Wang J, An M, Haubner BJ, Penninger JM. Cardiac regeneration: Options for repairing the injured heart. Front Cardiovasc Med 2023; 9:981982. DOI: https://doi.org/10.3389/fcvm.2022.981982
21. National Research Council (US) and Institute of Medicine (US) Committee on the Biological and Biomedical Applications of Stem Cell Research. Stem Cells and the Future of Regenerative Medicine. Washington (DC): National Academies Press (US); 2002. CHAPTER THREE, Embryonic Stem Cells. Available at: https://www.ncbi.nlm.nih.gov/books/NBK223690/
22. du Pré BC, Doevendans PA, van Laake LW. Stem cells for cardiac repair: An introduction. J Geriatr Cardiol 2013; 10(2):186-97. DOI: https://doi.org/10.3969/j.issn.1671-5411.2013.02.003
23. Uygur A, Lee RT. Mechanisms of cardiac regeneration. Dev Cell 2016; 36(4):362-374. DOI: https://doi.org/10.1016/j.devcel.2016.01.018
24. Pourtaji A, Jahani V, Moallem SMH, Karimani A, Mohammadpour AH. Application of G-CSF in congestive heart failure treatment. Curr Cardiol Rev 2019; 15(2):83-90. DOI: https://doi.org/10.2174/1573403X14666181031115118
25. Bernitz JM, Daniel MG, Fstkchyan YS, Moore K. Granulocyte colony-stimulating factor mobilizes dormant hematopoietic stem cells without proliferation in mice. Blood 2017; 129(14):1901-1912. DOI: https://doi.org/10.1182/blood-2016-11-752923
26. Carresi C, Scicchitano M, Scarano F, Macrì R, Bosco F, Nucera S, Ruga S, Zito MC, Mollace R, Guarnieri L, Coppoletta AR, Gliozzi M, Musolino V, Maiuolo J, Palma E, Mollace V. The potential properties of natural compounds in cardiac stem cell activation: Their role in myocardial regeneration. Nutrients 2021; 13(1):275. DOI: https://doi.org/10.3390/nu13010275
27. Raynaud CM, Ahmad FS, Allouba M, Abou-Saleh H, Lui KO, Yacoub M. Reprogramming for cardiac regeneration. Glob Cardiol Sci Pract 2014; 2014(3):309-329. DOI: https://doi.org/10.5339/gcsp.2014.44
28. Mancuso A, Barone A, Cristiano MC, Cianflone E, Fresta M, Paolino D. Cardiac stem cell-loaded delivery systems: A new challenge for myocardial tissue regeneration. Int J Mol Sci 2020; 21(20):7701. DOI: https://doi.org/10.3390/ijms21207701
29. Sharma V, Dash SK, Govarthanan K, Gahtori R, Negi N, Barani M, Tomar R, Chakraborty S, Mathapati S, Bishi DK, Negi P, Dua K, Singh SK, Gundamaraju R, Dey A, Ruokolainen J, Thakur VK, Kesari KK, Jha NK, Gupta PK, Ojha S. Recent advances in cardiac tissue engineering for the management of myocardium infarction. Cells 2021; 10(10):2538. DOI: https://doi.org/10.3390/cells10102538
30. Almeida SO, Skelton RJ, Adigopula S, Ardehali R. Arrhythmia in stem cell transplantation. Card Electrophysiol Clin 2015; 7(2):357-370. DOI: https://doi.org/10.1016/j.ccep.2015.03.012
31. Johnson RD, Lei M, McVey JH, Camelliti P. Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes. Cell Mol Life Sci 2023; 80(9):276. DOI: https://doi.org/10.1007/s00018-023-04924-3
32. White SJ, Chong JJH. Growth factor therapy for cardiac repair: An overview of recent advances and future directions. Biophys Rev 2020; 12(4):805-815. DOI: https://doi.org/10.1007/s12551-020-00734-0
33. Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009; 78(6):539-552. DOI: https://doi.org/10.1016/j.bcp.2009.04.029
34. Soliman AM, Barreda DR. Acute inflammation in tissue healing. Int J Mol Sci 2022; 24(1):641. DOI: https://doi.org/10.3390/ijms24010641
35. Ucuzian AA, Gassman AA, East AT, Greisler HP. Molecular mediators of angiogenesis. J Burn Care Res 2010; 31(1):158-75. DOI: https://doi.org/10.1097/BCR.0b013e3181c7ed82
36. Smagul S, Kim Y, Smagulova A, Raziyeva K, Nurkesh A, Saparov A. Biomaterials loaded with growth factors/cytokines and stem cells for cardiac tissue regeneration. Int J Mol Sci 2020; 21(17):5952. DOI: https://doi.org/10.3390/ijms21175952
37. Khosravi F, Ahmadvand N, Bellusci S, Sauer H. The multifunctional contribution of FGF signaling to cardiac development, homeostasis, disease and repair. Front Cell Dev Biol 2021; 9:672935. DOI: https://doi.org/10.3389/fcell.2021.672935
38. Roacho-Pérez JA, Garza-Treviño EN, Moncada-Saucedo NK, Carriquiry-Chequer PA, Valencia-Gómez LE, Matthews ER, Gómez-Flores V, Simental-Mendía M, Delgado-Gonzalez P, Delgado-Gallegos JL, Padilla-Rivas GR, Islas JF. Artificial scaffolds in cardiac tissue engineering. Life (Basel) 2022; 12(8):1117. DOI: https://doi.org/10.3390/life12081117
39. Carroll KJ, Makarewich CA, McAnally J, Anderson DM, Zentilin L, Liu N, Giacca M, Bassel-Duby R, Olson EN. A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9. Proc Natl Acad Sci U S A 2016; 113(2):338-343. DOI: https://doi.org/10.1073/pnas.1523918113
40. Major RJ, Poss KD. Zebrafish heart regeneration as a model for cardiac tissue repair. Drug Discov Today Dis Models 2007; 4(4):219-225. DOI: https://doi.org/10.1016/j.ddmod.2007.09.002
41. Ryan R, Moyse BR, Richardson RJ. Zebrafish cardiac regeneration-looking beyond cardiomyocytes to a complex microenvironment. Histochem Cell Biol 2020; 154(5):533-548. DOI: https://doi.org/10.1007/s00418-020-01913-6
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How to Cite
Mason, S. M. (2024). Human Cardiac Development and Regeneration Modeling. Science Insights, 45(2), 1465–1474. https://doi.org/10.15354/si.24.re1039
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