##plugins.themes.bootstrap3.article.main##

##plugins.themes.bootstrap3.article.sidebar##

Published Jan 31, 2025

Kazuya Wakai

Abstract

Participating in physical activities has been demonstrated to be one of the most efficacious natural methods for preventing and combating cancer. Research indicates that consistent physical activity can diminish the likelihood of getting specific cancer types, such as breast, colon, and lung cancer. Physical activity aids in sustaining a healthy body weight, enhancing immunological function, and diminishing inflammation—elements that collectively minimize cancer risk. Furthermore, physical activity can enhance the overall mental well-being and quality of life for individuals diagnosed with cancer and those in remission. Healthcare practitioners recommend that persons engage in a minimum of 150 minutes of moderate-intensity exercise weekly to obtain the cancer-preventive advantages of physical activity. Incorporating regular physical activity into one's lifestyle enables individuals to proactively mitigate their cancer risk and enhance overall well-being.

##plugins.themes.bootstrap3.article.details##

Keywords

Physical Activity, Prevention, Healthcare Strategy, Risk Reduction, Well-Being

Supporting Agencies

No funding source declared.

References
Anand, P., Kunnumakara, A. B., Sundaram, C., Harikumar, K. B., Tharakan, S. T., Lai, O. S., Sung, B., & Aggarwal, B. B. (2008). Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharmaceutical Research, 25(9), 2097–2116. DOI: https://doi.org/10.1007/s11095-008-9661-9

Ardies, C. M. (2002). Exercise, Cachexia, and Cancer Therapy: A Molecular Rationale. Nutrition and Cancer, 42(2), 143–157. DOI: https://doi.org/10.1207/s15327914nc422_1

Batty, D., & Thune, I. (2000). Does physical activity prevent cancer? BMJ, 321(7274), 1424–1425. DOI: https://doi.org/10.1136/bmj.321.7274.1424

Bianchini, F., Kaaks, R., & Vainio, H. (2002). Weight control and physical activity in cancer prevention. Obesity Reviews, 3(1), 5–8. DOI: https://doi.org/10.1046/j.1467-789x.2002.00046.x

Brown, J. C., & Ligibel, J. A. (2019). Putting exercise into oncology practice. The Cancer Journal, 25(5), 316–319. DOI: https://doi.org/10.1097/ppo.0000000000000397

Brown, J. C., Winters-Stone, K., Lee, A., & Schmitz, K. H. (2012). Cancer, physical activity, and exercise. Comprehensive Physiology, 2775–2809. DOI: https://doi.org/10.1002/cphy.c120005

Byers, T. (2002). The role of nutrition and nutrients in the prevention of chronic diseases. Primary Care Clinics in Office Practice, 29(3), 615–627. DOI: https://doi.org/10.1016/s0095-4543(02)00007-6

Cannioto, R., Etter, J. L., LaMonte, M. J., Ray, A. D., Joseph, J. M., Qassim, E. A., Eng, K. H., & Moysich, K. B. (2018). Lifetime physical inactivity is associated with lung cancer risk and mortality. Cancer Treatment and Research Communications, 14, 37–45. DOI: https://doi.org/10.1016/j.ctarc.2018.01.001

Chida, Y., Hamer, M., Wardle, J., & Steptoe, A. (2008). Do stress-related psychosocial factors contribute to cancer incidence and survival? Nature Clinical Practice Oncology, 5(8), 466–475. DOI: https://doi.org/10.1038/ncponc1134

D’Avanzo, B., Nanni, O., La Vecchia, C., Franceschi, S., Negri, E., Giacosa, A., Conti, E., Montella, M., Talamini, R., & Decarli, A. (1996). Physical activity and breast cancer risk. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 5(3), 155–160.

Eickmeyer, S. M., Gamble, G. L., Shahpar, S., & D, K., DO. (2012). The role and efficacy of exercise in persons with cancer. PM&R, 4(11), 874–881. DOI: https://doi.org/10.1016/j.pmrj.2012.09.588

Exercise in Regulation of Inflammation-Immune Axis Function in cancer initiation and Progression. (2015, December 1). PubMed. https://pubmed.ncbi.nlm.nih.gov/26676894

Ezzat, L., Peter, H., Bourquin, M., Busi, S. B., Michoud, G., Fodelianakis, S., Kohler, T. J., Lamy, T., Geers, A., Pramateftaki, P., Baier, F., Marasco, R., Daffonchio, D., Deluigi, N., Wilmes, P., Styllas, M., Schön, M., Tolosano, M., De Staercke, V., & Battin, T. J. (2025).
Diversity and biogeography of the bacterial microbiome in glacier-fed streams. Nature. DOI: https://doi.org/10.1038/s41586-024-08313-z

Friedenreich, C. M., & Orenstein, M. R. (2002). Physical activity and cancer prevention: etiologic evidence and biological mechanisms. Journal of Nutrition, 132(11), 3456S-3464S. DOI: https://doi.org/10.1093/jn/132.11.3456s

Gielen, S., Schuler, G., & Adams, V. (2010). Cardiovascular effects of exercise training. Circulation, 122(12), 1221–1238. DOI: https://doi.org/10.1161/circulationaha.110.939959

Hasler, C. M. (2002). Functional Foods: Benefits, Concerns and Challenges—A Position Paper from the American Council on Science and Health. Journal of Nutrition, 132(12), 3772–3781. DOI: https://doi.org/10.1093/jn/132.12.3772

International Agency for Research on Cancer (IARC). (2024). Weight control and physical activity. In IARC Handbooks of Cancer Prevention Volume 6. https://publications.iarc.fr/Book-And-Report-Series/Iarc-Handbooks-Of-Cancer-Prevention/Weight-Control-And-Physical-Activity-2002

Koelwyn, G. J., Wennerberg, E., Demaria, S., & Jones, L. W. (2015a, December 1). Exercise in Regulation of Inflammation-Immune Axis Function in cancer initiation and Progression. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909049

Koelwyn, G. J., Wennerberg, E., Demaria, S., & Jones, L. W. (2015b). Exercise in Regulation of Inflammation-Immune Axis Function in cancer initiation and Progression. Oncology (Williston Park), 29(12), 908–922.

Langevin, H. M., Weber, W., & Chen, W. (2023). Integrated multicomponent interventions to support healthy aging of the whole person. Aging Cell, 23(1). DOI: https://doi.org/10.1111/acel.14001

Lavery, J. A., Boutros, P. C., Knight, D., Tammela, T., Moskowitz, C. S., & Jones, L. W. (2024). Association of exercise with pan-cancer incidence and overall survival. Cancer Cell, 42(2), 169–171. DOI: https://doi.org/10.1016/j.ccell.2023.12.007

Lee, I. M., Sesso, H. D., & Paffenbarger, R. S. (1999). Physical activity and risk of lung cancer. International Journal of Epidemiology, 28(4), 620–625. DOI: https://doi.org/10.1093/ije/28.4.620

Miles, L. (2007). Physical activity and the prevention of cancer: a review of recent findings. Nutrition Bulletin, 32(3), 250–282. DOI: https://doi.org/10.1111/j.1467-3010.2007.00653.x

Morishita, S. (2016). Does physical exercise help to prevent cancer recurrence? International Journal of Physical Medicine & Rehabilitation, 4, 6. DOI: https://doi.org/10.4172/2329-9096.1000379

MSc, G. J. K., Wennerberg, E., PhD, Demaria, S., MD, & Jones, L. W., PhD. (2020, November 11). Exercise in Regulation of Inflammation-Immune Axis Function in cancer initiation and Progression. Cancer Network.

https://www.cancernetwork.com/view/exercise-regulation-inflammation-immune-axis-function-cancer-initiation-and-progression

Muscatell, K. A., & Eisenberger, N. I. (2012). A Social Neuroscience perspective on stress and health. Social and Personality Psychology Compass, 6(12), 890–904. DOI: https://doi.org/10.1111/j.1751-9004.2012.00467.x

Nigro, E., Perrotta, F., Scialò, F., D’Agnano, V., Mallardo, M., Bianco, A., & Daniele, A. (2021). Food, nutrition, physical activity and microbiota: Which impact on lung cancer? International Journal of Environmental Research and Public Health, 18(5), 2399. DOI: https://doi.org/10.3390/ijerph18052399

Orsini, N., Mantzoros, C. S., & Wolk, A. (2008). Association of physical activity with cancer incidence, mortality, and survival: a population-based study of men. British Journal of Cancer, 98(11), 1864–1869. DOI: https://doi.org/10.1038/sj.bjc.6604354

Shephard, R. J., & Freedson, P. (1996). Exercise and cancer: Linkages with obesity? Critical Reviews in Food Science and Nutrition, 36(4), 321–339. DOI: https://doi.org/10.1080/10408399609527728

Shephard, R. J., & Shek, P. N. (1995). Cancer, immune function, and physical activity. Canadian Journal of Applied Physiology, 20(1), 1–25. DOI: https://doi.org/10.1139/h95-001

Song, W., Derito, C. M., Liu, M. K., He, X., Dong, M., & Liu, R. H. (2010). Cellular antioxidant activity of common vegetables. Journal of Agricultural and Food Chemistry, 58(11), 6621–6629. DOI: https://doi.org/10.1021/jf9035832

Steindorf, K. (2013). The role of physical activity in primary cancer prevention. European Review of Aging and Physical Activity, 10(1), 33–36. DOI: https://doi.org/10.1007/s11556-012-0115-3

Tao, X., Chen, Y., Zhen, K., Ren, S., Lv, Y., & Yu, L. (2023). Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Physiology, 14. DOI: https://doi.org/10.3389/fphys.2023.1043108

Zapalac, K., Miller, M., Champagne, F. A., Schnyer, D. M., & Baird, B. (2024). The effects of physical activity on sleep architecture and mood in naturalistic environments. Scientific Reports, 14(1). DOI: https://doi.org/10.1038/s41598-024-56332-7
How to Cite
Wakai, K. (2025). Physical Activities: The Most Natural Preventive Way against Tumor. Science Insights, 46(1), 1701–1704. https://doi.org/10.15354/si.25.op246
Section
Opinion