Is There Neuroscientific Evidence of Burst of Lucidity in Dying People?
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Abstract
Reports of dying individuals exhibiting brief episodes of unexpected clarity, known as terminal lucidity or end-of-life rallies, have intrigued physicians, caregivers, and families for centuries. These moments, when people with advanced dementia, neurological decline, or prolonged unresponsiveness suddenly regain coherent speech, recognition, or purposeful behavior, raise profound questions about the brain at the threshold of death. Neuroscientific investigations into this phenomenon remain limited but increasingly suggest plausible mechanisms. Emerging evidence points to surges of neural activity, altered neurotransmitter dynamics, and cortical disinhibition during the dying process. Studies of near-death experiences, electroencephalographic recordings in humans, and experimental work in animals all reveal transient bursts of organized brain activity in the minutes surrounding cardiac arrest. While definitive proof is elusive, these findings indicate that lucidity in dying people may not be purely anecdotal but rather linked to measurable neurobiological processes. Understanding this mystery could illuminate consciousness itself and reshape perspectives on dying.
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Burst of Lucidity, Dying Period, Neuroscientific Evidence, Cognition, Consciousness
No funding source declared.
Borjigin, J., Lee, U., Liu, T., Pal, D., Huff, S., Klarr, D., Sloboda, J., Hernandez, J., Wang, M. M., & Mashour, G. A. (2013). Surge of neurophysiological coherence and connectivity in the dying brain. Proceedings of the National Academy of Sciences, 110(35), 14432–14437. DOI: https://doi.org/10.1073/pnas.1308285110
Charpier, S. (2023). Between life and death: the brain twilight zones. Frontiers in Neuroscience, 17. DOI: https://doi.org/10.3389/fnins.2023.1156368
Chawla, L., & Seneff, M. G. (2013). End-of-life electrical surges. Proceedings of the National Academy of Sciences, 110(44). DOI: https://doi.org/10.1073/pnas.1315409110
Chin, K., Chin, J., Tom, J., & Corona, A. (2024). A case series recognizing terminal lucidity in Non-Dementia hospice and palliative care patients. Journal of Pain and Symptom Management, 67(5), e668–e669. DOI: https://doi.org/10.1016/j.jpainsymman.2024.02.125
Iturria-Medina, Y., & Evans, A. C. (2015). On the central role of brain connectivity in neurodegenerative disease progression. Frontiers in Aging Neuroscience, 7. DOI: https://doi.org/10.3389/fnagi.2015.00090
Klapwijk, M. S., Caljouw, M. A., Van Soest-Poortvliet, M. C., Van Der Steen, J. T., & Achterberg, W. P. (2014). Symptoms and treatment when death is expected in dementia patients in long-term care facilities. BMC Geriatrics, 14(1). DOI: https://doi.org/10.1186/1471-2318-14-99
Koch, C. (2023). Do not go gently into that good night: The dying brain and its paradoxically heightened electrical activity. Proceedings of the National Academy of Sciences, 120(22). DOI: https://doi.org/10.1073/pnas.2305985120
Krooupa, A., Stone, P., McKeever, S., Seddon, K., Davis, S., Sampson, E. L., Tookman, A., Martin, J., Nambisan, V., & Vivat, B. (2022). Do palliative care patients and relatives think it would be acceptable to use Bispectral index (BIS) technology to monitor palliative care patients’ levels of consciousness? A qualitative exploration with interviews and focus groups for the I-CAN-CARE research programme. BMC Palliative Care, 21(1). DOI: https://doi.org/10.1186/s12904-022-00949-w
Lopatina, O. L., Malinovskaya, N. A., Komleva, Y. K., Gorina, Y. V., Shuvaev, A. N., Olovyannikova, R. Y., Belozor, O. S., Belova, O. A., Higashida, H., & Salmina, A. B. (2019). Excitation/inhibition imbalance and impaired neurogenesis in neurodevelopmental and neurodegenerative disorders. Reviews in the Neurosciences, 30(8), 807–820. DOI: https://doi.org/10.1515/revneuro-2019-0014
Mashour, G. A., Frank, L., Batthyany, A., Kolanowski, A. M., Nahm, M., Schulman‐Green, D., Greyson, B., Pakhomov, S., Karlawish, J., & Shah, R. C. (2019). Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias. Alzheimer S & Dementia, 15(8), 1107–1114. DOI: https://doi.org/10.1016/j.jalz.2019.04.002
Migliaccio, R., Tanguy, D., Bouzigues, A., Sezer, I., Dubois, B., Ber, I. L., Batrancourt, B., Godefroy, V., & Levy, R. (2020). Cognitive and behavioural inhibition deficits in neurodegenerative dementias. Cortex, 131, 265–283. DOI: https://doi.org/10.1016/j.cortex.2020.08.001
Nahm, M. (2009). Terminal lucidity in people with mental illness and other mental disability: An overview and implications for possible explanatory models. Journal of Near-Death Studies, 28(2), 87–106. DOI: https://doi.org/10.17514/jnds-2009-28-2-p87-106
Shlobin, N. A., Aru, J., Vicente, R., & Zemmar, A. (2023). What happens in the brain when we die? Deciphering the neurophysiology of the final moments in life. Frontiers in Aging Neuroscience, 15. DOI: https://doi.org/10.3389/fnagi.2023.1143848
Vicente, R., Rizzuto, M., Sarica, C., Yamamoto, K., Sadr, M., Khajuria, T., Fatehi, M., Moien-Afshari, F., Haw, C. S., Llinas, R. R., Lozano, A. M., Neimat, J. S., & Zemmar, A. (2022). Enhanced interplay of neuronal coherence and coupling in the dying human brain. Frontiers in Aging Neuroscience, 14. DOI: https://doi.org/10.3389/fnagi.2022.813531
Xu, G., Mihaylova, T., Li, D., Tian, F., Farrehi, P. M., Parent, J. M., Mashour, G. A., Wang, M. M., & Borjigin, J. (2023). Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain. Proceedings of the National Academy of Sciences, 120(19). DOI: https://doi.org/10.1073/pnas.2216268120
Zhang, Y., Li, Z., Zhang, J., Zhao, Z., Zhang, H., Vreugdenhil, M., & Lu, C. (2019). Near-Death High-Frequency Hyper-Synchronization in the rat hippocampus. Frontiers in Neuroscience, 13. DOI: https://doi.org/10.3389/fnins.2019.00800

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