Homeostatic Synaptic Plasticity: Balanced by COX2-PGE2 System to a New Setpoint

##plugins.themes.bootstrap3.article.main##

##plugins.themes.bootstrap3.article.sidebar##

Published Jul 15, 2013
DOI https://doi.org/10.15354/si.13.ar004

Fuzhou Wang  
Department of Anesthesiology and Intensive Care Medicine, the Affiliated Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, China.

Abstract

The setpoint of neural activity plays a critical role in maintaining the complex neural circuits into stable activities. Homeostatic synaptic plasticity is a major component of the setpoint theory that dynamically adjusts synaptic strengths. Cyclooxy-genase 2 (COX 2) is rapidly upregulated in inflammatory episodes after nervous injury and its product prostaglandin E2 (PGE2) exerts contrast functions in the nervous system by working on the homeostatic plasticity. New data revealed that COX2-PGE2 system takes an essential part in balancing excitation and inhibition of the synaptic activities at a new setpoint that finally is maintained by the homeostatic synaptic plasticity.

##plugins.themes.bootstrap3.article.details##

Keywords

Homeostatic Plasticity, Synapse, Cyclooxygenase 2, Prostaglandin E2, Inflammation, Electrophysiology

Supporting Agencies

This work is supported by the National Natural Scientific Foundation of China (NSFC, 30901397, 81271242) and the Nanjing Municipal Young Scientist Grant (201208009).

References
1. Turrigiano GG, Nelson SB. Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci 2004; 5: 97-107.

2. Trasande CA, Ramirez JM. Activity deprivation leads to seizures in hippocampal slice cultures: is epilepsy the consequence of homeostatic plasticity? J Clin Neurophysiol 2007; 24: 154-64.

3. Koch H, Huh SE, Elsen FP, Carroll MS, Hodge RD, Bedogni F, Turner MS, Hevner RF, Ramirez JM. Prostaglandin E2-induced synaptic plasticity in neocortical networks of organotypic slice cultures. J Neurosci 2010; 30: 11678-87.

4. De Simoni A, Griesinger CB, Edwards FA. Development of rat CA1 neurones in acute versus organotypic slices: role of experience in synaptic morphology and activity. J Physiol 2003; 550: 135-47.

5. Larsen M, Langmoen IA. The effect of volatile anaesthetics on synaptic release and uptake of glutamate. Toxicol Lett 1998; 100-101: 59-64.

6. Alonso-Nanclares L, Gonzalez-Soriano J, Rodriguez JR, DeFelipe J. Gender differences in human cortical synaptic density. Proc Natl Acad Sci USA 2008; 105: 14615-9.

7. Holtman L, van Vliet EA, Edelbroek PM, Aronica E, Gorter JA. Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. Epilepsy Res 2010; 91: 49-56.
How to Cite
Wang, F. (2013). Homeostatic Synaptic Plasticity: Balanced by COX2-PGE2 System to a New Setpoint. Science Insights, 1(2), 20–23. https://doi.org/10.15354/si.13.ar004
Issue
Vol. 1 No. 2 (2013)
Section
Original Article
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.