Adolescent Depressive Disorder and Gene Polymorphism
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Published
May 30, 2023
Abstract
Biogenetics plays an important role in the pathogenesis of adolescent depression and the study of gene polymorphisms has updated the understanding of adolescent depression. However, under the influence of gene-environment interaction and adolescent developmental age factors, the impact of gene polymorphisms on adolescent depression is intricate. Studying and elucidating the relationship between depression-related gene polymorphisms and adolescent depression contributes to the study of the pathogenesis of depression and provides new clues for the prevention and treatment of depression in adolescents. This article reviews the related gene polymorphisms around adolescent depression.
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Keywords
Depressive Disorder, Gene polymorphism, Adolescent, Pathogenesis
References
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3. Wu P, Hoven CW, Liu X, Cohen P, Fuller CJ, Shaffer D. Substance use, suicidal ideation and attempts in children and adolescents. Suicide Life Threat Behav 2004; 34(4):408-420. DOI: https://doi.org/10.1521/suli.34.4.408.53733
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5. Thapar A, Collishaw S, Pine DS, Thapar AK. Depression in adolescence. Lancet 2012; 379(9820):1056-1067. DOI: https://doi.org/10.1016/S0140-6736(11)60871-4
6. Remes O, Mendes JF, Templeton P. Biological, psychological, and social determinants of depression: A review of recent literature. Brain Sci 2021; 11(12):1633. DOI: https://doi.org/10.3390/brainsci11121633
7. Lohoff FW. Overview of the genetics of major depressive disorder. Curr Psychiatry Rep 2010; 12(6):539-546. DOI: https://doi.org/10.1007/s11920-010-0150-6
8. Defayette AB, Whitmyre ED, López R Jr, Brown B, Wolff JC, Spirito A, Esposito-Smythers C. Adolescent depressed mood and difficulties with emotion regulation: Concurrent trajectories of change. J Adolesc 2021; 91:1-14. DOI: https://doi.org/10.1016/j.adolescence.2021.07.001
9. Hodges MR, Richerson GB. Contributions of 5-HT neurons to respiratory control: Neuromodulatory and trophic effects. Respir Physiol Neurobiol 2008; 164(1-2):222-232. DOI: https://doi.org/10.1016/j.resp.2008.05.014
10. Kenna GA, Roder-Hanna N, Leggio L, Zywiak WH, Clifford J, Edwards S, Kenna JA, Shoaff J, Swift RM. Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: Review of psychopathology and pharmacotherapy. Pharmgenomics Pers Med 2012; 5:19-35. DOI: https://doi.org/10.2147/PGPM.S23462
11. Beevers CG, Wells TT, Ellis AJ, McGeary JE. Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. J Abnorm Psychol 2009; 118(3):670-681. DOI: https://doi.org/10.1037/a0016198
12. Goldman N, Glei DA, Lin YH, Weinstein M. The serotonin transporter polymorphism (5-HTTLPR): Allelic variation and links with depressive symptoms. Depress Anxiety 2010; 27(3):260-269. DOI: https://doi.org/10.1002/da.20660
13. Iurescia S, Seripa D, Rinaldi M. Looking beyond the 5-HTTLPR polymorphism: genetic and epigenetic layers of regulation affecting the serotonin transporter gene expression. Mol Neurobiol 2017; 54(10):8386-8403. DOI: https://doi.org/10.1007/s12035-016-0304-6
14. Avula R, Rand A, Black JL, O'Kane DJ. Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants. Transl Psychiatry 2011; 1(8):e32. DOI: https://doi.org/10.1038/tp.2011.34
15. Fratelli C, Siqueira J, Silva C, Ferreira E, Silva I. 5HTTLPR genetic variant and major depressive disorder: A review. Genes (Basel). 2020; 11(11):1260. DOI: https://doi.org/10.3390/genes11111260
16. Xia L, Yao S. The involvement of genes in adolescent depression: A systematic review. Front Behav Neurosci 2015; 9:329. DOI: https://doi.org/10.3389/fnbeh.2015.00329
17. Sarmiento-Hernández EI, Ulloa-Flores RE, Camarena-Medellín B, Sanabrais-Jiménez MA, Aguilar-García A, Hernández-Muñoz S. Association between 5-HTTLPR polymorphism, suicide attempt and comorbidity in Mexican adolescents with major depressive disorder. Actas Esp Psiquiatr 2019; 47(1):1-6.
18. Rao S, Leung CS, Lam MH, Wing YK, Waye MM, Tsui SK. Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese. Gene 2017; 603:34-41. DOI: https://doi.org/10.1016/j.gene.2016.12.006
19. Rocha TB, Hutz MH, Salatino-Oliveira A, Genro JP, Polanczyk GV, Sato JR, Wehrmeister FC, Barros FC, Menezes AM, Rohde LA, Anselmi L, Kieling C. Gene-environment interaction in youth depression: Replication of the 5-HTTLPR moderation in a diverse setting. Am J Psychiatry 2015; 172(10):978-985. DOI: https://doi.org/10.1176/appi.ajp.2015.14070896
20. Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Arch Gen Psychiatry 2011; 68(5):444-54. DOI: https://doi.org/10.1001/archgenpsychiatry.2010.189
21. Culverhouse RC, Saccone NL, Horton AC, Ma Y, Anstey KJ, Banaschewski T, Burmeister M, Cohen-Woods S, Etain B, Fisher HL, Goldman N, Guillaume S, Horwood J, Juhasz G, Lester KJ, Mandelli L, Middeldorp CM, Olié E, Villafuerte S, Air TM, Araya R, Bowes L, Burns R, Byrne EM, Coffey C, Coventry WL, Gawronski KAB, Glei D, Hatzimanolis A, Hottenga JJ, Jaussent I, Jawahar C, Jennen-Steinmetz C, Kramer JR, Lajnef M, Little K, Zu Schwabedissen HM, Nauck M, Nederhof E, Petschner P, Peyrot WJ, Schwahn C, Sinnamon G, Stacey D, Tian Y, Toben C, Van der Auwera S, Wainwright N, Wang JC, Willemsen G, Anderson IM, Arolt V, Åslund C, Bagdy G, Baune BT, Bellivier F, Boomsma DI, Courtet P, Dannlowski U, de Geus EJC, Deakin JFW, Easteal S, Eley T, Fergusson DM, Goate AM, Gonda X, Grabe HJ, Holzman C, Johnson EO, Kennedy M, Laucht M, Martin NG, Munafò MR, Nilsson KW, Oldehinkel AJ, Olsson CA, Ormel J, Otte C, Patton GC, Penninx BWJH, Ritchie K, Sarchiapone M, Scheid JM, Serretti A, Smit JH, Stefanis NC, Surtees PG, Völzke H, Weinstein M, Whooley M, Nurnberger JI Jr, Breslau N, Bierut LJ. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol Psychiatry 2018; 23(1):133-142. DOI: https://doi.org/10.1038/mp.2017.44
22. Juhasz G, Gonda X, Hullam G, Eszlari N, Kovacs D, Lazary J, Pap D, Petschner P, Elliott R, Deakin JF, Anderson IM, Antal P, Lesch KP, Bagdy G. Variability in the effect of 5-HTTLPR on depression in a large European population: The role of age, symptom profile, type and intensity of life stressors. PLoS One 2015; 10(3):e0116316. DOI: https://doi.org/10.1371/journal.pone.0116316
23. van Dalfsen JH, Markus CR. The involvement of sleep in the relationship between the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and depression: A systematic review. J Affect Disord 2019; 256:205-212. DOI: https://doi.org/10.1016/j.jad.2019.05.047
24. Emon MPZ, Das R, Nishuty NL, Shalahuddin Qusar MMA, Bhuiyan MA, Islam MR. Reduced serum BDNF levels are associated with the increased risk for developing MDD: A case-control study with or without antidepressant therapy. BMC Res Notes 2020; 13(1):83. DOI: https://doi.org/10.1186/s13104-020-04952-3
25. Sheikh HI, Hayden EP, Kryski KR, Smith HJ, Singh SM. Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR. Psychiatr Genet 2010; 20(3):109-112. DOI: https://doi.org/10.1097/YPG.0b013e32833a2038
26. Kanellopoulos D, Gunning FM, Morimoto SS, Hoptman MJ, Murphy CF, Kelly RE, Glatt C, Lim KO, Alexopoulos GS. Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression. Am J Geriatr Psychiatry 2011; 19(1):13-22. DOI: https://doi.org/10.1097/jgp.0b013e3181f61d62
27. Lee Y, Lim SW, Kim SY, Chung JW, Kim J, Myung W, Song J, Kim S, Carroll BJ, Kim DK. Association between the BDNF Val66Met polymorphism and chronicity of depression. Psychiatry Investig 2013; 10(1):56-61. DOI: https://doi.org/10.4306/pi.2013.10.1.56
28. Mikhailova SV, Ivanoshchuk DE, Yushkevich EA, Bairqdar A, Anisimenko MS, Shcherbakova LV, Denisova DV, Orlov PS. Prevalence of common alleles of some stress resilience genes among adolescents born in different periods relative to the socioeconomic crisis of the 1990s in Russia. Curr Issues Mol Biol 2022; 45(1):51-65. DOI: https://doi.org/10.3390/cimb45010004
29. Rimay T, Benak I, Kiss E, Baji I, Feher A, Juhasz A, Strauss J, Kennedy J, Barr C, Kovacs M, Vetro A, Kapornai K; International Consortium of Childhood-Onset Mood disorders. BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression. Psychiatr Genet 2015; 25(6):249-255. DOI: https://doi.org/10.1097/YPG.0000000000000107
30. Terracciano A, Piras MG, Lobina M, Mulas A, Meirelles O, Sutin AR, Chan W, Sanna S, Uda M, Crisponi L, Schlessinger D. Genetics of serum BDNF: Meta-analysis of the Val66Met and genome-wide association study. World J Biol Psychiatry 2013; 14(8):583-589. DOI: https://doi.org/10.3109/15622975.2011.616533
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How to Cite
Seelent, E. M. (2023). Adolescent Depressive Disorder and Gene Polymorphism. Science Insights, 42(5), 929–934. https://doi.org/10.15354/si.23.re327
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Review
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